Doris Grau
Lunchlady Doris / ... (23 episodes, 1991-1997)
Frank Welker
Santa's Little Helper / ... (20 episodes, 1991-2014)
Jon Lovitz
Artie Ziff / ... (15 episodes, 1991-2015)
Jackie Mason
Rabbi Hyman Krustofski / ... (8 episodes, 1991-2016)
Terry Greene
Additional Voices / ... (8 episodes, 2003-2013)
Stacy Keach
Howard K. Duff VII / ... (6 episodes, 2001-2016)
Jan Hooks
Manjula Nahasapeemapetilon (6 episodes, 1997-2002)
Michael York
Dr. Lionel Budgie / ... (5 episodes, 2006-2017)
Michael Dees
'Easter Parade' Vocals / ... (5 episodes, 1997-2013)
Dana Gould
Additional Voices / ... (5 episodes, 2002-2016)
Eric Idle
Declan Desmond (4 episodes, 2003-2012)
Ken Burns
Himself / ... (3 episodes, 2003-2012)
Valerie Harper
Department of Standardized Testing Proctor / ... (3 episodes, 2013-2017)
Stan Lee
Stan Lee (3 episodes, 2002-2017)
Alex Rocco
Roger Meyers Jr. (3 episodes, 1990-1997)
Sab Shimono
Additional Voices / ... (3 episodes, 1991-2007)
Dan Rather
Dan Rather / ... (2 episodes, 2008-2016)
R. Lee Ermey
Colonel Leslie Hapablap (2 episodes, 1995-2015)
Ron Taylor
Bleeding Gums Murphy (3 episodes, 1990-2013)
Jay Leno
Himself / ... (2 episodes, 1998-2016)
Kristen Wiig
Agent Annie Crawford / ... (2 episodes, 2011-2013)
Dick Tufeld
'Lost in Space' Robot / ... (2 episodes, 1998-2004)
Steve Allen
Bart's Electronically Altered Voice / ... (2 episodes, 1992-1995)
Seth Rogen
Lyle McCarthy / ... (2 episodes, 2009-2014)
Paul Rudd
Dr. Zander / ... (2 episodes, 2011-2014)
Adam West
Batman / ... (2 episodes, 1992-2002)
Teller
Himself / ... (2 episodes, 1999-2011)
Kipp Lennon
Flaming Moe's Song Vocalist / ... (2 episodes, 1991)
Greg Berg
'Hooray for Everything' Announcer / ... (1 episode, 1990)
Tom Poston
Capital City Goofball (1 episode, 1990)
Bret Hart
Bret 'The Hitman' Hart (1 episode, 1997)
Jon Hamm
FBI Investigator (1 episode, 2010)
Bill Burr
Boston Football Fan (1 episode, 2016)
Jim Lau
Hong Kong Doctor (1 episode, 1996)
Bono
Himself (2 episodes, 1998-2002)
The Edge
Himself (2 episodes, 1998-2002)
Joe C.
Joe C. (1 episode, 2000)
Mr. T
Mr. T (1 episode, 2003)
Common
Common (1 episode, 2017)
June Foray
Happy Little Elf / ... (1 episode, 1990)
Larry McKay
Football's Greatest Injuries Narrator (1 episode, 1991)
Marie Cain
Performer - 'I've Got You Under My Skin' (1 episode, 2004)
Sting
Sting (1 episode, 1992)
NRBQ
Themselves (1 episode, 1999)
Jay Mohr
Christopher Walken (1 episode, 2000)
Jerry Lewis
Professor John Frink, Sr. (1 episode, 2003)
Adrian Stout
Performer - End Credits Theme (1 episode, 2012)
RZA
RZA (1 episode, 2017)
Flea
Flea (1 episode, 1993)
Bob Joyce
Additional vocals (1 episode, 2006)
Jason Nash
Philanthropic Southies / ... (1 episode, 2016)
B-Real
Himself (1 episode, 1996)
Tom Kite
Himself (2 episodes, 1996-2000)
Jack Ong
Chinese Fisherman (1 episode, 1998)
Ben Bledsoe
Ralph Wiggum's Singing Voice (1 episode, 2001)
Marc Terenzi
Millhouse Van Houten's Singing Voice (1 episode, 2001)
Mike Scully
Magic Palace announcer (uncredited) (1 episode, 2000)